2011, Vol.14, No.3, pp.278-281
Latest findings provided evidences of the important role of reactive oxygen species in
cellular signal processes. In this study we examined the action of hydrogen peroxide on
synaptic transmission in the hippocampus. Millimolar concentrations of hydrogen peroxide
decreased fEPSP amplitude evoked in the CA1 region of rat hippocampal slices. GABAA
receptors antagonist picrotoxin, ryanodine receptors antagonist dantrolene, ATP-sensitive
potassium channels antagonist tolbutamide had no influence on the inhibitory effect of
hydrogen peroxide whereas non-specific adenosine receptors antagonist caffeine blocked
fEPSP depression by hydrogen peroxide, indicating that synaptic transmission inhibition
involved adenosine receptors activation. Pretreatment of slices with hydrogen peroxide before
the addition of adenosine had no effect on the fEPSP depression caused by adenosine
suggesting that functional properties of adenosine receptors are not affected by hydrogen
peroxide.
Key words:
ROS, hippocampus, hydrogen peroxide, adenosine receptors
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