Nonlinear Phenomena in Complex Systems, 2011, Vol.14, No.3, pp.282-289

NONLINEAR PHENOMENA IN COMPLEX SYSTEMS
An Interdisciplinary Journal

2011, Vol.14, No.3, pp.282-289

IR Fourier–Spectroscopy and Pharmacological Properties of Phenols.
G. B. Tolstorozhev, M. V. Belkov, I. V. Skornyakov, G. I. Polozov, V. L. Sorokin, G. A. Ksendzova, and O. I. Shadyro

IR Fourier spectra of pharmacologically active phenol molecules in solutions and crystals in CCl₄ are studied. The analysis of the screened phenols has shown that phenols with free hydroxyl groups possess the most antimicrobial activity. The manifestation of antiviral activity of aminophenols is associated with forming intramolecular hydrogen bonds in solutions. Phenyl-containing aminophenols, which have high activity against herpes virus, are characterized by the formation of the O-H...N-type intramolecular hydrogen bond. The main sign of high activity of aminophenols against group A virus is the predominance of the O-H...O=C-type intramolecular hydrogen bond. Sulfur-containing aminophenols, which show their activity against HIV-infection, have hydrogen bonds with O-H-, N-H- and SO₂ -groups in solutions and crystals.
Key words: IR spectrum, phenol, hydrogen bond, antiviral activity

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