2011, Vol.14, No.3, pp.290-294
During this work method of fluorescent probes with differently charged
fluorescent dyes was used for estimation of binding ability of the blood
plasma main transport proteins. Investigations were done at the patients
with liver cirrhosis for creating on those basis fluorescent tests adapted
for clinical use. Such tests should use for depending of severity degree of
pathological process and for the correct choice of the most effective
haemosorbent for extracorporeal blood purification in the definite clinical
situation. Regularity was shown for the changes in the binding ability of
the blood plasma main transport proteins in liver cirrhosis, which depended
on the stage of the disease and allowed efficiently estimate severity degree
of pathological process. Comparative evaluation of the efficacy of different
charcoal haemosorbents widely used in clinical practice as well as
"Prometheus" device was done in terms of endogenous intoxication syndrome
correction at liver cirrhosis patients using results of biochemical analysis
and method of fluorescent dyes. It was shown that the most effective
sorbents were sorbents of "Prometheus" and between charcoal heamosorbents
- "Carbocol".
Key words:
fluorescent probe, liver cirrhosis, heamosorbent,
Prometheus
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